Journal
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
Volume 3, Issue 6, Pages 424-431Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TBCAS.2009.2031329
Keywords
Dielectrophoresis; electroporation; lysis; optical manipulation; optoelectronic tweezers
Funding
- Center for Cell Control
- National Institute of Health Nanomedicine Development Center [PN2 EY018228]
- NATIONAL EYE INSTITUTE [PN2EY018228] Funding Source: NIH RePORTER
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Optoelectronic tweezers (OET) is a promising approach for the parallel manipulation of single cells for a variety of biological applications. By combining the manipulation capabilities of OET with other relevant biological techniques (such as cell lysis and electroporation), one can realize a true parallel, single-cell diagnostic and stimulation tool. Here, we demonstrate the utility of the OET device by integrating it onto single-chip systems capable of performing in-situ, electrode-based electroporation/lysis, individual cell, light-induced lysis, and light-induced electroporation.
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