Accelerated Motion Corrected Three-Dimensional Abdominal MRI Using Total Variation Regularized SENSE Reconstruction

Purpose: Develop a nonrigid motion corrected reconstruction for highly accelerated free-breathing three-dimensional (3D) abdominal images without external sensors or additional scans. Methods: The proposed method accelerates the acquisition by undersampling and performs motion correction directly in the reconstruction using a general matrix description of the acquisition. Data are acquired using a self-gated 3D golden radial phase encoding trajectory, enabling a two stage reconstruction to estimate and then correct motion of the same data. In the first stage total variation regularized iterative SENSE is used to reconstruct highly undersampled respiratory resolved images. A nonrigid registration of these images is performed to estimate the complex motion in the abdomen. In the second stage, the estimated motion fields are incorporated in a general matrix reconstruction, which uses total variation regularization and incorporates k-space data from multiple respiratory positions. The proposed approach was tested on nine healthy volunteers and compared against a standard gated reconstruction using measures of liver sharpness, gradient entropy, visual assessment of image sharpness and overall image quality by two experts. Results: The proposed method achieves similar quality to the gated reconstruction with nonsignificant differences for liver sharpness (1.18 and 1.00, respectively), gradient entropy (1.00 and 1.00), visual score of image sharpness (2.22 and 2.44), and visual rank of image quality (3.33 and 3.39). An average reduction of the acquisition time from 102 s to 39 s could be achieved with the proposed method. Conclusion: In vivo results demonstrate the feasibility of the proposed method showing similar image quality to the standard gated reconstruction while using data corresponding to a significantly reduced acquisition time. (C) 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance.