Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 74, Issue 1, Pages 42-50Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.25690
Keywords
intracerebral hemorrhage; stroke; APT imaging; CEST imaging; molecular imaging
Funding
- National Institutes of Health [R01-NS083435, R01-EB009731, R01-CA166171, R21-EB015555, K01-AG031926, R01-NS078026, R01-AT007317, R01-NS038684, R01-EB015032, P41-EB015909]
- American Heart Association [13GRNT15730001]
- National Natural Science Foundation of China [812111480]
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PurposeTo explore the capability of amide proton transfer (APT) imaging in the detection of hemorrhagic and ischemic strokes using preclinical rat models. MethodsThe rat intracerebral hemorrhage (ICH) model (n=10) was induced by injecting bacterial collagenase VII-S into the caudate nucleus, and the permanent ischemic stroke model (n=10) was induced by using a 4-0 nylon suture to occlude the origin of the middle cerebral artery. APT-weighted (APTw) MRI was acquired on a 4.7T animal imager and quantified using the magnetization transfer-ratio asymmetry at 3.5 ppm from water. ResultsThere was a consistently high APTw MRI signal in hyperacute ICH during the initial 12 h after injection of collagenase compared with the contralateral brain tissue. When hemorrhagic and ischemic stroke were compared, hyperacute ICH and cerebral ischemia demonstrated opposite APTw MRI contrastsnamely, hyperintense versus hypointense compared with contralateral brain tissue, respectively. There was a stark contrast in APTw signal intensity between these two lesions. ConclusionAPT-MRI could accurately detect hyperacute ICH and distinctly differentiate hyperacute ICH from cerebral ischemia, thus opening up the possibility of introducing to the clinic a single MRI scan for the simultaneous visualization and separation of hemorrhagic and ischemic strokes at the hyperacute stage. Magn Reson Med 74:42-50, 2015. (c) 2014 Wiley Periodicals, Inc.
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