Handheld Electromagnet Carrier for Transfer of Hyperpolarized Carbon-13 Samples

Purpose: Hyperpolarization of carbon-13 (C-13) nuclei by dissolution dynamic nuclear polarization increases signal-to-noise ratio (SNR) by > 10,000-fold for metabolic imaging, but care must be taken when transferring hyperpolarized (HP) samples from polarizer to MR scanner. Some C-13 substrates relax rapidly in low ambient magnetic fields. A handheld electromagnet carrier was designed and constructed to preserve polarization by maintaining a sufficient field during sample transfer. Methods: The device was constructed with a solenoidal electromagnet, powered by a nonmagnetic battery, holding the HP sample during transfer. A specially designed switch automated deactivation of the field once transfer was complete. Phantom and rat experiments were performed to compare MR signal enhancement with or without the device for HP [C-13] urea and [1-C-13] pyruvate. Results: The magnetic field generated by this device was tested to be > 50 G over a 6-cm central section. In phantom and rat experiments, [C-13] urea transported via the device showed SNR improvement by a factor of 1.8-1.9 over samples transferred through the background field. Conclusion: A device was designed and built to provide a suitably high yet safe magnetic field to preserve hyperpolarization during sample transfer. Comparative testing demonstrated SNR improvements of approximately two-fold for [C-13] urea while maintaining SNR for [1-C-13] pyruvate. (C) 2015 Wiley Periodicals, Inc.