Journal
IEEE SENSORS JOURNAL
Volume 10, Issue 1, Pages 137-144Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2009.2035738
Keywords
Biological gases; gas detectors; microsensors; multidimensional signal processing; nanotechnology
Funding
- National Institutes of Health
- National Institute of Standards and Technology
- National Research Council
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We evaluated a microelectromechanical systems (MEMS) microsensor array with temperature-controlled chemi-resistive elements for use as a noninvasive clinical diagnostic tool to detect the presence or absence of trace amounts of disease biomarkers in simulated breath samples. The microsensor environment was periodically altered between air (78% N(2), 21% O(2) by volume, 20% relative humidity) and simulated breath (77% N(2), 16% O(2), 4% CO(2) by volume, 80% relative humidity) samples creating a dynamic background. Acetone, a disease marker for diabetes, was spiked into select simulated breath samples at relevant concentrations (0.5 mu mol/ mol to 8 mu mol/mol) to pose a diagnostic problem for the sensor array. Using standard statistical dimensionality reduction and classification algorithms, we compared the ability of a variety of sensing materials to detect and recognize the disease marker. Our analyses indicate that the porous, doped nanoparticle materials (Sb:SnO(2) microshell films and Nb:TiO(2) nanoparticle films) are best for the recognition problem (acetone present versus absent), but that WO(3) and SnO(2) films are better at the quantification task (high versus low concentrations of acetone).
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