Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 36, Issue 23, Pages 2031-2041Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201500344
Keywords
hybrid vesicles; lipids; membranes; polymersomes; vesicles
Categories
Funding
- DFG within the Forschergruppe [BI 1337/6-1, BI 1337/7-2, FOR-1145]
- DFG [INST 271/249-1, INST 271/274-1, INST 271/248-1]
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Vesicles can be individually fabricated from naturally occurring lipid or synthetic block copoly mer molecules via self-assembly in aqueous solutions; the blending of both vesicle-forming amphiphiles leads to the formation of hybrid membranes. Their final stabilities and lateral morphologies are strongly determined by the molar composition, size, and charge properties of the interacting components as well as by the lipid chain melting temperature. Upon merging the best properties of lipo- and polymersomal membranes, hybrid lipid/polymer vesicles represent a new scaffold for medical applications combining, e.g., combining the biocompatibility of liposomes with the high thermal and mechanical stability and functional variability of polymersomes within a single vesicle type. Up to now, several hybrid membrane systems and their corresponding vesicular morphologies have been studied, highlighting the attractive properties and features useful in selective delivery receptor scaffolding.
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