Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 36, Issue 15, Pages 1444-1449Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201500207
Keywords
cancer therapy; explosion; layer-by-layer; photothermal effects; polyelectrolyte multilayers
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Funding
- HIT
- China Postdoctoral Science Foundation [2013M531019]
- New Century Excellent Talent Program [NCET-11-0800]
- Fundamental Research Funds for the Central Universities
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Gold nanoshell-functionalized polymer multilayer tubes can be used as potent therapeutic agents for remote killing of cancer cells in a controlled manner due to the emerging pressure wave and tube fragments piercing the cell wall. The explosion is based on rapid evaporation of water inside the tubes caused by photothermal effects. The mechanism of explosion is presented in theory and experiment. The explosion of the tubes depends on the absorption coefficient and size of the gold nanoshells in the tubes, whereby the placement of the gold particles inside or outside of the tubes has no obvious effect on the explosive properties.
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