Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 12, Pages 1641-1646Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500226
Keywords
alginate particles; droplet microfluidics; antibody; drug delivery system
Funding
- Lithuanian Agency for Science, Innovation and Technology (MITA) [uVesicles 31v-40]
- European Union [VP1-3.1-SMM-01]
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Owing to their biocompatibility and reduced side effects, natural polymers represent an attractive choice for producing drug delivery systems. Despite few successful examples, however, the production of biopolymer-based particles is often hindered by considerable technical challenges mainly associated with high viscosity of polymer fluids. In this work, we present a microfluidic approach for production of alginate-based particles carrying encapsulated antibodies. We use a triple-flow microdevice to induce hydrogel formation inside droplets before their collection off-chip. The fast mixing and gelation process produced alginate particles with a unique biconcave shape and dimensions approaching those of mammalian cells. We show slow and fast dissolution of particles in different buffers and record controlled antibody release over time.
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