Journal
MACROMOLECULAR BIOSCIENCE
Volume 16, Issue 3, Pages 451-461Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500324
Keywords
bactericide activity; biocompatibility; cellulose carbamates; cellulose phenyl carbonates; microorganisms
Funding
- German Science Foundation (DFG) [HE 2054/15-1]
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Cellulose phenyl carbonates are an excellent platform to synthesize a broad variety of soluble and functional cellulose carbamates. In this study, the synthesis of cellulose carbamates with terminal amino groups, namely omega-aminoethylcellulose- and omega-aminoethyl-p-aminobenzylcellulose carbamate, is discussed. The products are well soluble and their structures can be clearly described by NMR spectroscopy. The cellulose carbamates exhibit a bactericide and fungicide activity in vitro. The omega- aminoethylcellulose carbamate possesses a strong activity against Candida albicans and Staphylococcus aureus (IC50 of 0.02 mg mL(-1) and 0.05 mg mL(-1)). The antimicrobial activity and cytotoxicity can be improved by p-amino-benzylamine (ABA) as an additional substituent. The mixed cellulose carbamate exhibits a high biocompatibility (LC50 of 3.18 mg mL(-1)) and forms films on cotton and PES, which exhibit a strong activity against S. aureus and Klebsiella pneumoniae [GRAPHICS] .
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