Journal
MACROMOLECULAR BIOSCIENCE
Volume 16, Issue 1, Pages 139-150Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500251
Keywords
bacterial cellulose; biocompatibility; endothelialization; mechanical properties; surface roughness; vascular grafts
Funding
- Portuguese Foundation for Science and Technology (FCT)
- European Community fund FEDER through Program COMPETE [FCOMP-01-0124-FEDER-007025 (PTDC/AMB/68393/2006), PEST-OE/EQB/LA0023/2013, PEST-C/FIS/UI607/2013, RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462)]
- Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER [NORTE-07-0124-FEDER-000048]
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/66094/2009]
- FCT through project BCGrafts [FCOMP-01-0124-FEDER-014773 (PTDC/EBB/EBI/112170/2009)]
- People Program (Marie Curie Actions) of the European Union [317512]
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Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose ( BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall produced a tensile strength above that of native vessels, performing similarly to the current commercial alternatives. As a result of the production method, the luminal surface of the graft presents similar topography to that of native vessels. We have also studied the in vivo behavior of these BC graft in order to further demonstrate their viability. In these preliminary studies, 1 month patency was achieved, with the presence of neo-vessels and endothelial cells on the luminal surface of the graft.
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