Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 11, Pages 1484-1489Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201500163
Keywords
protein nanoparticle; siRNA delivery; tat
Funding
- National Natural Science Foundation of China [91227118, 51373167, 21374117]
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Development of an innovative nucleic acid nanocarriers still represents a challenge. In this study, we develop a protein nanoparticle (H6-TatEGFP) and examine its siRNA condensing activity. Gel retardation assay show that protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes. UsingCy3-labelled siRNA, we also evaluate siRNA transport characteristic of protein nanoparticles in tumor cells, the results indicate that H6-TatEGFP nanoparticle may be a potential nanocarrier for siRNA in tumor cells.
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