Related references
Note: Only part of the references are listed.Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
Amita Datta-Mannan et al.
MABS (2015)
Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics
Angela Schoch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Antibodies to watch in 2015
Janice M. Reichert
MABS (2015)
The therapeutic monoclonal antibody market
Dawn M. Ecker et al.
MABS (2015)
Matching chelators to radiometals for radiopharmaceuticals
Eric W. Price et al.
CHEMICAL SOCIETY REVIEWS (2014)
Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?
Andreas Baumann et al.
DRUG DISCOVERY TODAY (2014)
Assessment of the metabolism of therapeutic proteins and antibodies
Eric Ezant et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2014)
Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
Hanne M. Kinnunen et al.
JOURNAL OF CONTROLLED RELEASE (2014)
Pharmacokinetics of Peptide-Fc Fusion Proteins
Benjamin Wu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Monoclonal antibody disposition: a simplified PBPK model and its implications for the derivation and interpretation of classical compartment models
Ludivine Fronton et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2014)
The effect of the neonatal Fc receptor on human IgG biodistribution in mice
Nancy Chen et al.
MABS (2014)
Quantitative cumulative biodistribution of antibodies in mice
Victor Yip et al.
MABS (2014)
Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge
Bing Li et al.
MABS (2014)
Imaging preclinical tumour models: improving translational power
Marion de Jong et al.
NATURE REVIEWS CANCER (2014)
Whole-body and microscopic autoradiography to determine tissue distribution of biopharmaceuticals - Target discoveries with receptor micro-autoradiography engendered new concepts and therapies for vitamin D
Walter E. Stumpf
ADVANCED DRUG DELIVERY REVIEWS (2013)
On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach
Nahor Haddish-Berhane et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2013)
Engineering synthetic vaccines using cues from natural immunity
Darrell J. Irvine et al.
NATURE MATERIALS (2013)
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
Aran F. Labrijn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools
Jean W. Lee
BIOANALYSIS (2013)
Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics
Surinder Kaur et al.
BIOANALYSIS (2013)
Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats
Yan Zou et al.
DRUG METABOLISM AND DISPOSITION (2013)
ADME of Biologics-What Have We Learned from Small Molecules?
Thomayant Prueksaritanont et al.
AAPS JOURNAL (2012)
Tissue Distribution Studies of Protein Therapeutics Using Molecular Probes: Molecular Imaging
Simon-Peter Williams
AAPS JOURNAL (2012)
ADME of Antibody-Maytansinoid Conjugates
Hans K. Erickson et al.
AAPS JOURNAL (2012)
Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics
Xin Xu et al.
AAPS JOURNAL (2012)
Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration
Wolfgang F. Richter et al.
AAPS JOURNAL (2012)
Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics
Daniela Bumbaca et al.
AAPS JOURNAL (2012)
Delivery of molecular and cellular medicine to solid tumors
Rakesh K. Jain
ADVANCED DRUG DELIVERY REVIEWS (2012)
Enzyme Replacement Therapy for Lysosomal Diseases: Lessons from 20 Years of Experience and Remaining Challenges
R. J. Desnick et al.
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 13 (2012)
Radiolabeled Absorption, Distribution, Metabolism, and Excretion Studies in Drug Development: Why, When, and How?
Natalia Penner et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2012)
Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism
Ben-Quan Shen et al.
CURRENT DRUG METABOLISM (2012)
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
Paul Morgan et al.
DRUG DISCOVERY TODAY (2012)
Preclinical in vivo ADME studies in drug development: a critical review
Mario Pellegatti
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Mechanistic Modeling of Antigen Sink Effect for Mavrilimumab Following Intravenous Administration in Patients With Rheumatoid Arthritis
Bing Wang et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
Dhaval K. Shah et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2012)
Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model
Cinthia V. Pastuskovas et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
Yanan Zheng et al.
MABS (2012)
Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice
Rong Deng et al.
MABS (2012)
Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys
Amita Datta-Mannan et al.
MABS (2012)
Marketed therapeutic antibodies compendium
Janice M. Reichert
MABS (2012)
Outlook for the next 5 years in drug innovation
Roy Berggren et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Investigation of the Mechanism of Clearance of AMG 386, a Selective Angiopoietin-1/2 Neutralizing Peptibody, in Splenectomized, Nephrectomized, and FcRn Knockout Rodent Models
Benjamin Wu et al.
PHARMACEUTICAL RESEARCH (2012)
Lymphatic Transport and Catabolism of Therapeutic Proteins after Subcutaneous Administration to Rats and Dogs
Weirong Wang et al.
DRUG METABOLISM AND DISPOSITION (2012)
Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody-Drug Conjugates in Rats
C. Andrew Boswell et al.
BIOCONJUGATE CHEMISTRY (2011)
Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors
Stephen I. Rudnick et al.
CANCER RESEARCH (2011)
Strategies for extended serum half-life of protein therapeutics
Roland E. Kontermann
CURRENT OPINION IN BIOTECHNOLOGY (2011)
High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans
Andrew M. Goetze et al.
GLYCOBIOLOGY (2011)
PET with the 89Zr-Labeled Transforming Growth Factor-β Antibody Fresolimumab in Tumor Models
Thijs H. Oude Munnink et al.
JOURNAL OF NUCLEAR MEDICINE (2011)
The impact of glycosylation on monoclonal antibody conformation and stability
Kai Zheng et al.
MABS (2011)
Investigation of the Pharmacokinetics of Romiplostim in Rodents with a Focus on the Clearance Mechanism
Yow-Ming C. Wang et al.
PHARMACEUTICAL RESEARCH (2011)
Unique challenges of providing bioanalytical support for biological therapeutic pharmacokinetic programs
William L. Nowatzke et al.
BIOANALYSIS (2011)
Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease
Mohammad Tabrizi et al.
AAPS JOURNAL (2010)
On Setting the First Dose in Man: Quantitating Biotherapeutic Drug-Target Binding through Pharmacokinetic and Pharmacodynamic Models
Philip J. Lowe et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2010)
Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
C. Andrew Boswell et al.
BIOCONJUGATE CHEMISTRY (2010)
Biodistribution of 89Zr-trastuzumab and PET Imaging of HER2-Positive Lesions in Patients With Metastatic Breast Cancer
E. C. Dijkers et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Effect of Immune Complex Formation on the Distribution of a Novel Antibody to the Ovarian Tumor Antigen CA125
Cinthia V. Pastuskovas et al.
DRUG METABOLISM AND DISPOSITION (2010)
Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys
Rong Deng et al.
DRUG METABOLISM AND DISPOSITION (2010)
Automated screening of monoclonal antibodies for SISCAPA assays using a magnetic bead processor and liquid chromatography-selected reaction monitoring-mass spectrometry
Regine M. Schoenherr et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2010)
Physiologically Based Pharmacokinetic Model for T84.66: A Monoclonal Anti-CEA Antibody
Shweta R. Urva et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
The Application of Target Information and Preclinical Pharmacokinetic/Pharmacodynamic Modeling in Predicting Clinical Doses of a Dickkopf-1 Antibody for Osteoporosis
Alison M. Betts et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
Charge variants in IgG1 Isolation, characterization, in vitro binding properties and pharmacokinetics in rats
Leslie A. Khawli et al.
MABS (2010)
Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability
Hemant Sarin
VASCULAR CELL (2010)
Strategies and challenges for the next generation of therapeutic antibodies
Alain Beck et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Phase I Biodistribution and Pharmacokinetic Study of Lewis Y-Targeting Immunoconjugate CMD-193 in Patients with Advanced Epithelial Cancers
Rebecca A. Herbertson et al.
CLINICAL CANCER RESEARCH (2009)
Pharmacological significance of glycosylation in therapeutic proteins
Huijuan Li et al.
CURRENT OPINION IN BIOTECHNOLOGY (2009)
Nonfucosylated rituximab potentiates human neutrophil phagocytosis through its high binding for FcγRIIIb and MHC class II expression on the phagocytotic neutrophils
Mami Shibata-Koyama et al.
EXPERIMENTAL HEMATOLOGY (2009)
Biodistribution of a Bispecific Single-chain Diabody and Its Half-life Extended Derivatives
Roland Stork et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity
Stephen C. Alley et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Menaka Sarav et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
Michael M. Schmidt et al.
MOLECULAR CANCER THERAPEUTICS (2009)
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
Volker Schellenberger et al.
NATURE BIOTECHNOLOGY (2009)
Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action
Royston Jefferis
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Assessing immunogenicity in the presence of excess protein therapeutic using immunoprecipitation and quantitative mass spectrometry
Hendrik Neubert et al.
ANALYTICAL CHEMISTRY (2008)
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
W. Wang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs
Jasmine P. Davda et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2008)
N-glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies
Roland Stork et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Evidence for an Asialoglycoprotein Receptor on Nonparenchymal Cells for O-Linked Glycoproteins
Eric G. Stefanich et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Molecular imaging in drug development
Juergen K. Willmann et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Properties of the glomerular barrier and mechanisms of proteinuria
Borje Haraldsson et al.
PHYSIOLOGICAL REVIEWS (2008)
Podocytes use FcRn to clear IgG from the glomerular basement membrane
Shreeram Akilesh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model
Leonid Kagan et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2007)
Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice
Amit Garg et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2007)
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence Imaging agent for monoclonal antibody tumor-targeted imaging
Heng Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A phase I biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3s193 in patients with advanced epithelial cancers that express the Lewis-Y antigen
Andrew M. Scott et al.
CLINICAL CANCER RESEARCH (2007)
Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms
William C. Aird
CIRCULATION RESEARCH (2007)
Phenotypic heterogeneity of the endothelium II. Representative vascular beds
William C. Aird
CIRCULATION RESEARCH (2007)
PEGylated proteins: Evaluation of their safety in the absence of definitive metabolism studies
Rob Webster et al.
DRUG METABOLISM AND DISPOSITION (2007)
FcRn: the neonatal Fc receptor comes of age
Derry C. Roopenian et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors
William S. Sly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles
Sai T. Reddy et al.
JOURNAL OF APPLIED PHYSIOLOGY (2006)
Impact of variable domain glycosylation on antibody clearance: An LC/MS characterization
LH Huang et al.
ANALYTICAL BIOCHEMISTRY (2006)
Evaluation of Tc-99m-MAG(3)-annexin V: influence of the chelate on in vitro and in vivo properties in mice
JL Vanderheyden et al.
NUCLEAR MEDICINE AND BIOLOGY (2006)
A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal fc receptor (FcRn)
GZ Ferl et al.
ANNALS OF BIOMEDICAL ENGINEERING (2005)
Pharmacokinetic-pharmacodynamic-efficacy analysis of efalizumab in patients with moderate to severe psoriasis
CM Ng et al.
PHARMACEUTICAL RESEARCH (2005)
Allometric scaling of mammalian metabolism
CR White et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2005)
On the prediction of the human response: A recycled mechanistic pharmacokinetic/pharmacodynamic approach
GML Meno-Tetang et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)
Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice
HS Xie et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Pharmacokinetic and biodistribution profile of recombinant human interleukin-10 following intravenous administration in rats with extensive liver fibrosis
H Rachmawati et al.
PHARMACEUTICAL RESEARCH (2004)
Antibody pharmacokinetics and pharmacodynamics
ED Lobo et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2004)
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
KJ Hamblett et al.
CLINICAL CANCER RESEARCH (2004)
Delivery of therapeutic agents to the central nervous system: the problems and the possibilities
DJ Begley
PHARMACOLOGY & THERAPEUTICS (2004)
Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
P Caliceti et al.
ADVANCED DRUG DELIVERY REVIEWS (2003)
Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET
I Verel et al.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2003)
Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-β1a monkeys
DE Mager et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Effect of pegylation on pharmaceuticals
JM Harris et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Glycosylation of erythropoietin affects receptor binding kinetics: Role of electrostatic interactions
RJ Darling et al.
BIOCHEMISTRY (2002)
PEGylated antibodies and antibody fragments for improved therapy: a review
AP Chapman
ADVANCED DRUG DELIVERY REVIEWS (2002)
Pharmacokinetics of murine anti-human CD3 antibodies in man are determined by the disappearance of target antigen
RT Meijer et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
General pharmacokinetic model for drugs exhibiting target-mediated drug disposition
DE Mager et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2001)
Quantitative whole-body autoradiography in the pharmaceutical industry - Survey results on study design, methods, and regulatory compliance
EG Solon et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2001)