Journal
IEEE JOURNAL OF SOLID-STATE CIRCUITS
Volume 44, Issue 5, Pages 1644-1654Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSSC.2009.2016994
Keywords
Biosensor; CMOS image sensor; fluorescence; microarray
Categories
Funding
- NHGRI NIH HHS [R33 HG003089-04, R33 HG003089-03, R33 HG003089] Funding Source: Medline
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This paper describes the design of an active, integrated CMOS sensor array for fluorescence applications which enables time-gated, time-resolved fluorescence spectroscopy. The 64-by-64 array is sensitive to photon densities as low as 8.8 x 10(6) photons/cm(2) with 64-point averaging and, through a differential pixel design, has a measured impulse response of better than 800 ps. Applications include both active microarrays and high-frame-rate imagers for fluorescence lifetime imaging microscopy.
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