Journal
LWT-FOOD SCIENCE AND TECHNOLOGY
Volume 61, Issue 1, Pages 158-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.lwt.2014.11.014
Keywords
Houttuynia cordata; Methylgiyoxal; Advanced glycation end products; Trapping; Quercitrin
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Funding
- National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) [2014R1A2A2A01007627]
- National Research Foundation of Korea [2014R1A2A2A01007627] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The inhibitory effect of bioactive components from Houttuynia cordata (H. cordata) on advanced glycation end-products (AGEs) by trapping methylglyoxal (MGO). was investigated. MGO and its adducts of quercitrin, chlorogenic acid, rutin was analyzed by using liquid chromatography-mass spectrometry (LC-MS/MSn). The remaining MGO were 523, 26.7, and 9.4% for chlorogenic acid, quercitrin, and rutin, respectively and the mono- or di-MGO conjugated adducts of quercitrin and rutin were identified at 24 h of reaction. The formation of AGEs was detected through the reaction of glucose with protein by the fluorescence method. During the glycation reaction, quercitrin, rutin, and methanol extract of H. cordata decreased the production level of AGEs by 91-94.6 %. H. cordata containing chlorogenic acid, quercitrin, and rutin may have potential role in minimizing AGEs formation. (C) 2014 Elsevier Ltd. All rights reserved.
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