Journal
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Volume 18, Issue 3, Pages 1244-1259Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSTQE.2011.2181991
Keywords
Molecular diffusion; optical clearing; optical coherence tomography
Categories
Funding
- Institute of Biomedical Imaging Sciences [IBIS-97708]
- NIH/NHLBI [T32-HL07812]
- AHA [11POST7430064]
- Civilian Research and Development Foundation [RUB1-2932-SR-08]
- National Science Foundation [CMMI-0900743]
- Russian Foundation for Basic Research [10-07-00526-a]
- FP7-ICT-2007-2 [224014 PHOTONICS4LIFE]
- RF Ministry of Education and Science [1.4.09, 2.1.1/4989, 2.2.1.1/2950]
- RF [02.740.11.0484, 02.740.11.0770, 02.740.11.0879]
- FiDiPro, TEKES Program, Finland [40111/11]
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In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.
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