Journal
IEEE ELECTRON DEVICE LETTERS
Volume 35, Issue 3, Pages 333-335Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/LED.2014.2298397
Keywords
AlGaAs/GaAs; HEMT; biosensor
Categories
Funding
- National Natural Science Foundation of China [21307130, 61106004, 61204012, 61274049, 61376058]
- Beijing Natural Science Foundation [4132070]
- Beijing Nova Program [2010B056]
- NNSF Outstanding Youth Fund [50625205]
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Alpha-fetoprotein (AFP) is a typical tumor marker in early diagnosis. Highly specific detection of the AFP was demonstrated using AlGaAs/GaAs high electron mobility transistors (HEMTs). Anti-AFP antibody was immobilized to the Au-coated gate area of the HEMT by a covalent modification method. To avoid any nonspecific binding, the gate was blocked by bovine serum albumin after the reduction of the carbonyl group. A detection limit for the AFP as low as a few picograms/milliliter was achieved, and cross reactivity of the sensor was found negligible, demonstrating its high selectivity. Successful detection with minute quantity of the sample indicates that the sensor has great potential in practical screening for a wide population.
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