Journal
LUMINESCENCE
Volume 30, Issue 7, Pages 1083-1089Publisher
WILEY-BLACKWELL
DOI: 10.1002/bio.2862
Keywords
quantum dot; fluorescence quenching; salicylic acid
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Funding
- TRF-CHE grant [MRG5680045]
- Thailand Research Fund
- Commission on Higher Education, Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- National Research University Project of Thailand
- Trace Analysis and Biosensor Research Center, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand
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Mercaptopropionic acid (MPA)-capped cadmium telluride (CdTe) quantum dot (QDs) fluorescent probes were synthesized in aqueous solution and used for the determination of salicylic acid. The interaction between the MPA-capped CdTe QDs and salicylic acid was studied using fluorescence spectroscopy and some parameters that could modify the fluorescence were investigated to optimize the measurements. Under optimum conditions, the quenched fluorescence intensity of MPA-capped CdTe QDs was linearly proportional to the concentration of salicylic acid in the range of 0.5-40 mu g mL(-1) with a coefficient of determination of 0.998, and the limit of detection was 0.15 mu g mL(-1). The method was successfully applied to the determination of salicylic acid in pharmaceutical products, and satisfactory results were obtained that were in agreement with both the high pressure liquid chromatography (HPLC) method and the claimed values. The recovery of the method was in the range 99 +/- 3% to 105 +/- 9%. The proposed method is simple, rapid, cost effective, highly sensitivity and eminently suitable for the quality control of pharmaceutical preparation. The possible mechanisms for the observed quenching reaction was also discussed. Copyright (C) 2015 John Wiley & Sons, Ltd.
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