Journal
LIVER INTERNATIONAL
Volume 36, Issue 5, Pages 713-720Publisher
WILEY
DOI: 10.1111/liv.12977
Keywords
epidemiology; insulin resistance; metabolic syndrome; non-alcoholic fatty liver disease; TG; HDL ratio
Categories
Funding
- AstraZeneca plc
- Astellas Pharma Inc.
- Bristol-Myers Squibb K.K.
- Daiichi Sankyo Co., Ltd.
- Eli Lilly Japan K.K.,
- Kyowa Hakko Kirin Company Ltd.
- Kowa Pharmaceutical Co., Ltd.
- Kissei Pharmaceutical Co., Ltd.
- MSD K.K.
- Mitsubishi Tanabe Pharma Corporation
- Novo Nordisk Pharma Ltd.
- Nippon Chemiphar Company Ltd.
- Sanwa Kagaku Kenkyusho Co., Ltd.
- Sanofi K.K.
- Taisho Toyama Pharmaceutical Co., Ltd.
- Takeda Pharmaceutical Co., Ltd.
- TERUMO Co.
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BackgroundTriglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) has been recommended for surrogates of insulin resistance. However, it remains to be elucidated the association between TG/HDL-C and incident fatty liver. AimsTo investigate the association between TG/HDL-C and incident fatty liver. MethodsWe performed population-based historical cohort study consisted with 4518 healthy Japanese who received yearly health-checkup programmes over decade. Fatty liver was diagnosed using ultrasonography. ResultsDuring the observation periods, 38.8% (case/N = 1023/2637) of men and 17.2% (case/N = 324/1881) of women developed fatty liver. Adjusting odds ratio of TG/HDL-C for incident fatty liver were 1.59 (95% confidence interval (CI) 1.42-1.79, P < 0.0001) in men and 2.50 (95% CI 1.80-3.51, P < 0.0001) in women. In addition, adjusting odds ratio of TG/HDL-C for incident non-alcoholic fatty liver disease were 1.55 (95% CI 1.35-1.77, P < 0.0001) in men and 2.72 (95% CI 1.88-3.95, P < 0.0001) in women. According to the receiver operator characteristic (ROC) analysis, the optimal cut-off point of TG/HDL-C for incident fatty liver was 0.88 (area under the ROC curve (AUC) 0.67 [95% CI 0.65-0.69], sensitivity = 0.64, specificity = 0.60, P < 0.0001) in men and 0.64 (AUC 0.69 [95% CI 0.66-0.72], sensitivity = 0.50, specificity = 0.78, P < 0.0001) in women. ConclusionsThe TG/HDL-C could predict the incident fatty liver. Thus, it is important to check TG/HDL-C and lifestyles modification is needed for preventing future fatty liver disease in patients with high TG/HDL-C.
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