Journal
HYPERTENSION IN PREGNANCY
Volume 28, Issue 3, Pages 300-311Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641950802601237
Keywords
Case-control study; Cell biology; Inflammation; Preeclampsia; Pregnancy
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Objective: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients. Methods: Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry. Results: Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells. Conclusion: We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.
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