Journal
LIFE SCIENCES
Volume 126, Issue -, Pages 19-27Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2015.01.026
Keywords
Sulforaphane; NK cells; MICA/MICB; ROS; Ionizing radiation
Funding
- Bhabha Atomic Research Centre, Government of India
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Aims: The goal of this study is to investigate the tumor cytotoxic effects of sulforaphane (SFN) and ionizing radiation (IR) as well as their ability to up-regulate natural killer group 2, member D (NKG2D) ligands and modulate the susceptibility of tumor cells to natural killer (NK) cell-mediated killing. Main methods: Expression of MHC class I-related chain molecules A and B (MICA/MICB) and total reactive oxygen species (ROS) were assessed by flow cytometry following labeling with appropriate dyes or antibodies. NK cell cytotoxicity was determined by calcein release of target cells. Key findings: The expression of NKG2D ligands MICA/MICB was found to vary in all the four tumor cell lines tested (MCF7
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