Journal
LEUKEMIA RESEARCH
Volume 39, Issue 7, Pages 769-772Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2015.04.014
Keywords
NUP98 translocations; Leukaemia; Lineage affiliation; Single cell analysis
Categories
Funding
- Fondo per gli investimenti della Ricerca di Base (FIRB) [RBAP11TF7Z-005]
- Associazione italiana per la Ricerca sul Cancro [AIRC I.C. 11512]
- Fondazione Cassa di Risparmio
- Perugia Programmi di ricerca scientifica di rilevante interesse nazionale (PRIN) [2014.0265.021, 08010101]
Ask authors/readers for more resources
We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always affected a CD34+/CD133+ hematopoietic precursor. Interestingly the abnormal clone included myelomonocytes, erythroid cells, B- and T-lymphocytes in MDS/AML and only CD7+/CD3+ cells in T-ALL. The NUP98-RAP1GDS1 affected different hematopoietic lineages in AML and T-ALL. Additional specific genomic events, were identified, namely FLT3 and CEBPA mutations in MDS/AML, and NOTCH1 mutations and MYB duplication in T-ALL. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available