Journal
LEUKEMIA & LYMPHOMA
Volume 56, Issue 9, Pages 2498-2504Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2015.1011640
Keywords
Lymphoma; anti-tumour immunity; T cells
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The tumor microenvironment in B-cell non-Hodgkin lymphoma (NHL) comprises not only malignant cells but also significant numbers of normal immune cells. The intratumoral immune infiltrate includes T-lymphocytes that appear to target the malignant clone. Despite immunologically recognizing the lymphoma cells, the intratumoral T-cells are unable to eradicate the malignant cells and the lymphoma commonly progresses. Recent data has identified mechanisms whereby activated intratumoral T-cells are suppressed or become exhausted due to chronic antigen stimulation. A clearer understanding of these mechanisms will allow for strategies to overcome them and improve the outcome of patients with lymphoma.
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