Journal
HUMAN VACCINES
Volume 6, Issue 6, Pages 494-505Publisher
LANDES BIOSCIENCE
DOI: 10.4161/hv.6.6.12008
Keywords
Vaccine; premature infants; impaired immune defences
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Newborn infants, particularly those born prematurely are at increased risk of infections, including vaccine preventable ones, resulting in an increased morbidity and mortality risk. Defects associated with higher mortality may involve external barriers and the innate and adaptive systems. The available evidence suggests a complex situation that ranges from pathogen/immunogen non-responsiveness to fully mature adult-equivalent functionality depending on both host and vaccine characteristics. This review considers potential qualitative and quantitative differences with respect to immune defences between premature/term infants and adults and evaluates implications of such differences for immunisation outcomes.
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