Journal
HUMAN REPRODUCTION
Volume 24, Issue 10, Pages 2395-2400Publisher
OXFORD UNIV PRESS
DOI: 10.1093/humrep/dep256
Keywords
diminished ovarian reserve; premature ovarian failure (POF); premature ovarian aging (POA); FMR1 gene; autoimmunity
Categories
Funding
- Foundation for Reproductive Medicine
- Center for Human Reproduction - New York
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It is unknown whether etiologies differ between milder forms of premature ovarian senescence (the acronym given here 'premature ovarian aging, POA'), and premature ovarian failure (POF). We assessed presumed pathophysiologies in 74 consecutive POA patients, diagnosed based on elevated age-specific baseline follicle stimulating hormone and/or abnormally low anti-Mullerian hormone levels (< 1.5 ng/ml). A genetic etiology was presumed with >= 34 triple CGG expansions on the FMR1 gene. An autoimmune etiology was assumed with at least one abnormality in a laboratory panel, involving antinuclear, antiphospholipid and thyroid antibodies, total immunoglobulin levels and anti-ovarian as well as anti-adrenal autoantibodies. A combined etiology was presumed with both autoimmune and genetic etiologies, and a patient was considered idiopathic when no abnormalities were found. Twelve of 74 (16.2%) women demonstrated a genetic, 28 (37.8%) an autoimmune, 9 (12.2%) combined and 25 (33.8%) idiopathic etiologies. Presumed underlying etiologies with POA follow a similar distribution pattern as reported for POF. POA and POF may, therefore, represent a continuum in phenotypical expression of different etiologies of premature ovarian senescence. Like POF, POA should be considered reason to investigate underlying etiologies.
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