Journal
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Volume 26, Issue 1, Pages 41-50Publisher
WILEY
DOI: 10.1002/hup.1168
Keywords
depression; remission; anxiety; parasuicide; Korea
Funding
- Ministry of Health and Welfare, Republic of Korea [A050047]
- NIHR Biomedical Research Centre for Mental Health
- South London and Maudsley NHS Foundation Trust
- Institute of Psychiatry, King's College London
- Ministry of Health & Welfare and National Research Foundation of Korea
- Lundbeck
- Sanofi-Aventis
- Janssen
- Ministry of Health & Welfare of Korea
- Ministry of Health, Welfare and Family Affairs of Korea
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Objective To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea. Methods For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of <= 7 sustained to 12 weeks or last follow-up, if earlier. Results For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety. Conclusions Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and previous suicide attempt were markers of worse outcome. Copyright (C) 2011 John Wiley & Sons, Ltd.
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