Journal
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Volume 26, Issue 6, Pages 440-443Publisher
WILEY-BLACKWELL
DOI: 10.1002/hup.1218
Keywords
QT interval; prolactin; olanzapine; dose-effect; side effect
Funding
- Japan Society for the Promotion of Research (JSPS) [17591199, 19591344, 20591362]
- Mitsubishi Pharma Research Foundation
- Health and Labour Sciences Research Grants [H17-kokoro-002]
- Grants-in-Aid for Scientific Research [19591344, 17591199] Funding Source: KAKEN
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Objectives There have been few reports regarding olanzapine (OLZ)-related QT prolongation and hyperprolactinemia. This study evaluated the dose-dependent effect of OLZ on QT interval and plasma prolactin (PRL) level in a single sample of patients with schizophrenia. Methods Twenty-six subjects treated with varying starting doses of OLZ were enrolled in the study. Following baseline assessments, which included completion of the Brief Psychiatric Rating Scale (BPRS), measurements of Body Mass Index (BMI), QT interval, electrolytes, fasting plasma glucose, PRL, hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL), the dose of OLZ was increased for each subject. The same parameters were evaluated following the increased dose treatment. Results A significant decrease was observed in BPRS score (p=0.01) following treatment with an increased dose of OLZ. Significant increases were observed in BMI (p=0.032), QTc (p=0.031), and plasma PRL level (p=0.028). The mean values of electrolytes, fasting plasma glucose, HbA1c, TC, TG, HDL and LDL treatment were unchanged by the switch to increased-dose OLZ treatment. Conclusion We have demonstrated the dose-dependent effect of OLZ on the QT interval and the plasma PRL level of patients with schizophrenia. Copyright (C) 2011 John Wiley & Sons, Ltd.
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