Journal
HUMAN PATHOLOGY
Volume 45, Issue 2, Pages 259-267Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2013.05.029
Keywords
NY-ESO-1; Melanoma; Cancer testis antigen; Immunotherapy
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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New York esophageal squamous cell carcinoma-1 (NY-ESO-1), a cancer testis antigen, is an ideal target for adoptive cell transfer immunotherapy. Evidence from several clinical trials in melanoma and other malignancies shows the potential value of targeting the NY-ESO-1 antigen in immune-based therapy of metastatic tumors. However, the incidence of NY-ESO-1 expression in metastatic melanoma is unknown, and thus, it is unclear how many patients might benefit from this therapy. In this study, we analyzed NY-ESO-1 expression in 222 melanoma specimens, including 16 primary and 206 metastatic tumors. Our results support previous fmdings showing higher expression of NY-ESO-1 in metastatic (58/206; 28.2%) versus primary (0/16) tumors. In addition, our results show that the epithelioid subtype of melanoma has the highest incidence of NY-ESO-1 expression. These findings provide evidence of the value of this specific adoptive cell transfer therapy for the treatment of metastatic melanoma. Published by Elsevier Inc.
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