Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 12, Issue 4, Pages 314-318Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180811666141010000435
Keywords
1,2,3-thiadiazole; 1,3,4-thiadiazole; bioactivity; synthesis; thiourea
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Funding
- National Natural Science Foundation of China [21002090]
- Key Innovation Team of Science and Technology in Zhejiang Province [2010R50018-06]
- National Key Technologies RD Program [2011BAE06B03-01]
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In order to investigate the biological activity of novel thiourea compounds, some novel 1,2,3-thiadiazole derivatives containing 1,3,4-thiadiazole were synthesized under phase transfer catalyzed condition (PEG-600) by multi-step reactions. The chemical structures of all compounds were established by H-1 NMR, FTIR, MS, and elemental analysis, and some of these compounds were investigated for fungicidal activity and plant growth regulatory activity. The bioassay results indicated that some of these compound exhibited moderate activities.
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