Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 12, Issue 4, Pages 253-258Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180811666141010220427
Keywords
Alendronate; mechanism; optimization; phosphorus oxychloride; phosphorous acid; risedronic acid; synthesis
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Funding
- Hungarian Scientific Research Found (OTKA) [K83118]
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The synthesis of risedronic acid and alendronate from 3-pyridylacetic acid and aminobutyric acid, respectively, using phosphorus oxychloride and phosphorous acid as the P-reagents and methanesulfonic acid as the solvent was optimized, and the role of phosphorus oxychloride and phosphorous acid in the reaction was clarified.
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