Journal
HUMAN PATHOLOGY
Volume 43, Issue 9, Pages 1524-1529Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2012.01.019
Keywords
Perictyoma; ACTB; GLI1
Categories
Funding
- NCI NIH HHS [U10 CA098543, U10 CA098543-07S4] Funding Source: Medline
Ask authors/readers for more resources
Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed pericytoma with t(7;12). To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available