Journal
HUMAN PATHOLOGY
Volume 40, Issue 2, Pages 270-278Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2008.06.013
Keywords
Pituitary; TSH cell carcinoma; De novo malignancy; Plurihormonality; Ultrastructure; MEN-1 syndrome
Categories
Funding
- Mitsubishi Company, Tokyo, Japan
- Lloyd-Carr-Harris Foundation
Ask authors/readers for more resources
Pituitary carcinomas are exceedingly rare. At present, the sole diagnostic criterion is metastatic spread, either craniospinal or systemic. There is no agreement oil a histologic, immunohistochemical, and/or Ultrastructural definition. We report a clinically and morphologically well-documented example of pituitary thyrotropin cell carcinoma in a man with multiple endocrine neoplasia type I syndrome. The tumor produced thyrotropin, a-subunit, and prolactin and, through electron microscopy, was found to consist solely of Thyrotroph cells. Over a protracted course, craniospinal and systemic metastases were noted. The primary and metastatic deposits of this aggressive tumor were studied. To our knowledge, this tumor is the first reported case of thyrotropin cell carcinoma occurring in association with the multiple endocrine neoplasia type I syndrome. The literature regarding thyrotropin carcinomas is reviewed. Based on the study of several biopsies during disease progression, we believe that the carcinoma originated de novo without an intermediary adenoma phase. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available