Journal
HUMAN PATHOLOGY
Volume 39, Issue 2, Pages 209-212Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2007.06.004
Keywords
glypican-3; Ki-67; hepatitis C; immunohistochemistry
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Glypican 3 is an oncofetal antigen that shows great promise as an adjunct to the diagnosis of hepatocellular carcinoma. To investigate whether glypican 3 might also appear in nonneoplastic liver cells, we performed immunostains on 60 biopsies of chronic hepatitis C, 30 with low-grade activity and 30 with high-grade activity. Glypican 3 immunoreactivity was detected in 25 (83.6%) of 30 in the high-grade but in none in the low-grade group. In 20% of the positive cases, glypican 3 produced strong cytoplasmic staining of more than 25% of hepatocytes and could potentially lead to a misdiagnosis of hepatocellular carcinoma. Pathologists should be aware of this phenomenon and exercise caution in interpreting biopsies or other specimens of suspected hepatocellular carcinoma when active necroinflammatory disease is present. (C) 2008 Published by Elsevier Inc.
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