Journal
HUMAN MUTATION
Volume 33, Issue 7, Pages 1123-1132Publisher
WILEY
DOI: 10.1002/humu.22089
Keywords
breast cancer susceptibility; polymorphisms; genome-wide association; risk factors; hormone receptor status; 11q13
Categories
Funding
- European Community [223175, HEALTH-F2-2009-223175]
- Cancer Research UK [C1287/A10118, C1287/A12014]
- European Union COST [BM0606]
- United States National Cancer Institute, National Institutes of Health (NIH) [RFA-CA-06-503]
- Cancer Prevention Institute of California [U01 CA69417]
- University of Melbourne [U01 CA69638]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Dutch Cancer Society [NKI DCS 2007-3839, 2009-4363, UL1997-1505]
- Dutch National Genomics Initiative
- Breast Cancer Research Trust
- ELAN of the University Hospital of Erlangen
- Cancer Research UK
- Breakthrough Breast Cancer
- NHS
- National Cancer Research Network (NCRN)
- NIHR Comprehensive Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust
- King's College London
- Oxford Biomedical Research Centre
- Dietmar-Hopp Foundation
- Helmholtz Society
- German Cancer Research Center (DKFZ)
- Fondation de France [2004012618, 2007005156]
- Institut National du Cancer (INCa) [2007-1 SPC2, 2008-1-CP-4, 2009-1-SHS SP-04]
- Association pour la Recherche contre le Cancer (ARC) [2008-1-CP-4]
- Genome Spain Foundation
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra el Cancer
- Fondo de Investigacion Sanitario [PI081583, PI081120]
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev Hospital
- Baden Wurttemberg Ministry of Science, Research and Arts
- German Cancer Aid (Deutsche Krebshilfe) [107054]
- Federal Ministry of Education and Research (BMBF), Germany [01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114]
- Robert Bosch Foundation, Stuttgart
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany
- Stichting tegen Kanker [232-2008, 196-2010]
- German Cancer Research Centre (DKFZ)
- Rudolf Bartling Foundation
- Hannover Medical School
- Helsinki University Central Hospital
- Academy of Finland [132473]
- Finnish Cancer Society
- Sigrid Juselius Foundation
- German Academic Exchange Program
- Friends of Hannover Medical School
- German Federal Ministry of Research and Education [RUS08/017]
- Swedish Cancer Society
- Gustav V Jubilee Foundation
- National Breast Cancer Foundation
- NHMRC
- Queensland Cancer Fund
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- NHMRC [145684, 288704, 454508, 199600, 209057, 251533, 396414, 504711, 504715]
- United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Kuopio University Hospital
- Cancer Fund of North Savo
- Finnish Cancer Organizations
- Academy of Finland
- University of Eastern Finland
- Deutsche Krebshilfe e.V. [70-2892-BR I]
- Hamburg Cancer Society
- German Cancer Research Center
- Federal Ministry of Education and Research (BMBF) Germany [01KH0402]
- Ministero della Salute
- Ministero dell'Universita' e Ricerca [RBLAO3-BETH]
- Fondazione Italiana per la Ricerca sul Cancro
- Associazione Italiana per la Ricerca sul Cancro [4017]
- NIH [CA122340, CA128978, CA58860, CA92044]
- Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201]
- Cancer Council Victoria
- Norwegian Research council [155218/V40, 175240/S10]
- FUGE-NFR [181600/V11]
- Swizz Bridge Award
- Finnish Cancer Foundation
- University of Oulu
- Oulu University Hospital
- National Cancer Institute, Department of Health and Human Services, USA
- Yorkshire Cancer Research
- Breast Cancer Campaign
- Ministry of Health and Welfare, Republic of Korea [AO30001]
- Polish Foundation of Science
- Institute of Biomedical Sciences, Academia Sinica, Taiwan
- Lon V Smith Foundation [LVS39420]
- Dutch Cancer Society d [UL1997-1505]
- Biobanking and Biomolecular Resources Research Infrastructure [BBMRI-NL CP16]
- Institute of Cancer Research
- [PBZ_KBN_122/P05/2004]
- Cancer Research UK [11022, 10118] Funding Source: researchfish
- Cancer Research UK
- The Francis Crick Institute [10119, 10124] Funding Source: researchfish
- National Institute for Health Research [03/DHCS/03/G121/51] Funding Source: researchfish
Ask authors/readers for more resources
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P = 3 X 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 X 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype. Hum Mutat 33:11231132, 2012. (c) 2012 Wiley Periodicals, Inc.
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