Journal
HUMAN MUTATION
Volume 31, Issue 6, Pages 623-630Publisher
WILEY
DOI: 10.1002/humu.21252
Keywords
cohesin; genome instability; cancer; Cornelia de Lange syndrome; Roberts syndrome
Categories
Funding
- Istituto Toscano Tumori
- Fondazione Cassa di Risparmio delle Provincie Lombarde
- Consiglio Nazionale delle Ricerche (CNR, RSTI.)
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Cohesin is responsible for sister chromatid cohesion, ensuring the correct chromosome segregation. Beyond this role, cohesin and regulatory cohesin genes seem to play a role in preserving genuine stability and gene transcription regulation. DNA damage is thought to be a major culprit for many human diseases, including cancer. Our present knowledge of the molecular basis underlying genome instability is extremely limited. Mutations in cohesin genes cause human diseases such as Cornelia de Lange syndrome and Roberts syndrome/Sc phocomelia, and all the cell lines derived from affected patients show genome instability. Cohesin mutations have also been identified in colorectal cancer. Here, we will discuss the human disorders caused by alterations of cohesin function, with emphasis on the emerging role of cohesin as a genome stability caretaker. Hum Mutat 31:623-630, 2010. (C) 2010 Wiley-Liss, Inc.
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