Journal
HUMAN MUTATION
Volume 31, Issue 1, Pages E1052-E1057Publisher
WILEY
DOI: 10.1002/humu.21141
Keywords
genetic susceptibility; breast cancer risk; miRNA; rs11614913; rs3746444; rs2910164
Categories
Funding
- Fondazione Italiana per la Ricerca sul Cancro
- Special Project Hereditary tumors
- Associazione Italiana per la Ricerca sul Cancro [4017]
- Ministero della Salute
- Ricerca Oncologica-Project of integrated program
- Progetto Tumori Femminili
- Ministero dell'Istruzione, Universita' e Ricerca [RBLAO3-BETH]
- Deutsche Krebshilfe [107054]
- Helmholtz Society, The German Cancer Research Center (DKFZ)
- Dietmar Hopp Foundation
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Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease-causing mutations or unclassified variants in BRCA1 and BRCA2, and 2760 controls from Germany and Italy. We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis. None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset. (C) 2009 Wiley-Liss, Inc.
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