Journal
HUMAN MUTATION
Volume 30, Issue 4, Pages E566-E569Publisher
WILEY
DOI: 10.1002/humu.20989
Keywords
Alzheimer disease; CALHM1; genetic; association
Categories
Funding
- National Institute on Aging [AG030653, AG05133]
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A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No association with risk of late-onset Alzheimer disease (p = 0.368 for genotypes; p = 0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p = 0.034). (C) 2009 Wiley-Liss, Inc.
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