Related references
Note: Only part of the references are listed.KLHL2 interacts with and ubiquitinates WNK kinases
Daiei Takahashi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms
Yutaro Mori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
Akihito Ohta et al.
BIOCHEMICAL JOURNAL (2013)
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation
Guojin Wu et al.
FEBS LETTERS (2013)
Dietary Salt Intake Regulates WNK3-SPAK-NKCC1 Phosphorylation Cascade in Mouse Aorta Through Angiotensin II
Moko Zeniya et al.
HYPERTENSION (2013)
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron
Emmanuelle Vidal-Petiot et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
Shigeru Shibata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension
Mai Wakabayashi et al.
CELL REPORTS (2013)
WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone
Koichiro Susa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Effect of heterozygous deletion of WNK1 on the WNK-OSR1/SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels
Koichiro Susa et al.
CLINICAL AND EXPERIMENTAL NEPHROLOGY (2012)
Enhanced phosphorylation of Na+-Cl- co-transporter in experimental metabolic syndrome: role of insulin
Radko Komers et al.
CLINICAL SCIENCE (2012)
Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice
Hidenori Nishida et al.
HYPERTENSION (2012)
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
Lynn M. Boyden et al.
NATURE (2012)
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process
Maria Castaneda-Bueno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo
Katsuyuki Oi et al.
BIOLOGY OPEN (2012)
Overexpression of the Sodium Chloride Cotransporter Is Not Sufficient to Cause Familial Hyperkalemic Hypertension
James A. McCormick et al.
HYPERTENSION (2011)
WNK1 Regulates Vasoconstriction and Blood Pressure Response to α1-Adrenergic Stimulation in Mice
Sonia Bergaya et al.
HYPERTENSION (2011)
Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation
Yu Kigoshi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth
Mei-Yao Lin et al.
JOURNAL OF CELL BIOLOGY (2011)
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade
Motoko Chiga et al.
JOURNAL OF CELL SCIENCE (2011)
Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling
Joo-ri Kim-Kaneyama et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2011)
Acute Insulin Stimulation Induces Phosphorylation of the Na-Cl Cotransporter in Cultured Distal mpkDCT Cells and Mouse Kidney
Eisei Sohara et al.
PLOS ONE (2011)
Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome
Shih-Hua Lin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium
James B. Wade et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)
Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney
Gulibaha Talati et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
Yu-Ru Lee et al.
EMBO JOURNAL (2010)
Role of the WNK-activated SPAK kinase in regulating blood pressure
Fatema H. Rafiqi et al.
EMBO MOLECULAR MEDICINE (2010)
SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction
Sung-Sen Yang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure
Akihito Ohta et al.
HUMAN MOLECULAR GENETICS (2009)
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway
David J. Rozansky et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway
Pedro San-Cristobal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone
Motoko Chiga et al.
KIDNEY INTERNATIONAL (2008)
Molecular pathogenesis of pseudohypoaldosteronism type II:: Generation and analysis of a Wnk4D561A/+ knockin mouse model
Sung-Sen Yang et al.
CELL METABOLISM (2007)
Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation
Eisei Sohara et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo
Michelle O'Reilly et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
T Moriguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
AC Vitari et al.
BIOCHEMICAL JOURNAL (2005)
Simple and highly efficient BAC recombineering using gaIK selection
S Warming et al.
NUCLEIC ACIDS RESEARCH (2005)
A highly efficient recombineering-based method for generating conditional knockout mutations
PT Liu et al.
GENOME RESEARCH (2003)
Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice:: Role of renin genes
Q Wang et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2002)
Phenotypic and genetic heterogeneity of familial hyperkalaemic hypertension (Gordon syndrome)
JM Achard et al.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2001)
Human hypertension caused by mutations in WNK kinases
FH Wilson et al.
SCIENCE (2001)