Journal
HUMAN MOLECULAR GENETICS
Volume 22, Issue 17, Pages 3597-3607Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddt205
Keywords
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Funding
- National Institutes of Health [R01HD057194, HHSN268200625226C, R01-HD012252, R01-HD053685, R01-DK064391, R01-AR052147]
- National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC- 55020, N01-HC-55021, N01-HC-55022, R01HL087641, R01HL59367, R01HL086694]
- National Human Genome Research Institute [U01HG004402]
- National Center for Research Resources (NCRR) [UL1 RR 025005]
- Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02, 076113/B/04/Z]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Human Genome Research Institute (NHGRI)
- National Institute of Child Health and Human Development (NICHD)
- Juvenile Diabetes Research Foundation International (JDRF)
- EUROSPAN (European Special Populations Research Network)
- European Commission FP6 STRP [018947, LSHG-CT-2006-01947]
- Netherlands Organization for Scientific Research
- Erasmus MC
- Centre for Medical Systems Biology (CMSB)
- Netherlands Brain Foundation (HersenStichting Nederland)
- ENGAGE
- OPENGENE
- Estonian Government [SF0180142s08]
- Estonian Research Roadmap through Estonian Ministry of Education and Research [3.2.0304.11-0312]
- Center of Excellence in Genomics (EXCEGEN)
- University of Tartu [SP1GVARENG]
- National Heart, Lung and Blood Institute's Framingham Heart Study [N01-HC-25195]
- Affymetrix, Inc. [N02-HL-6-4278]
- Department of Medicine at Boston University School of Medicine
- Boston Medical Center
- NIH [R01HD057194]
- National Institutes of Dental and Craniofacial Research [U01-DE018903]
- NIDCR [R01-DE 014899]
- National Institutes of Health (NIH) [HHSN268200782096C]
- NIDCR through CIDR's NIH
- National Institutes of Health (Boston Obesity Nutrition Research Center) [HL71981, DK46200]
- American Heart Association [0730094N]
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403, 03IS2061A, 03ZIK012]
- Ministry of Cultural Affairs
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Siemens Healthcare, Erlangen, Germany
- Federal State of Mecklenburg-West Pomerania
- National Institute on Aging (NIA) and National Institutes of Health (NIH) [NO1-AG-1-2109]
- [U01 DK062418]
- MRC [G0000934] Funding Source: UKRI
- Medical Research Council [G0000934] Funding Source: researchfish
Ask authors/readers for more resources
Genetic loci for body mass index (BMI) in adolescence and young adulthood, a period of high risk for weight gain, are understudied, yet may yield important insight into the etiology of obesity and early intervention. To identify novel genetic loci and examine the influence of known loci on BMI during this critical time period in late adolescence and early adulthood, we performed a two-stage meta-analysis using 14 genome-wide association studies in populations of European ancestry with data on BMI between ages 16 and 25 in up to 29 880 individuals. We identified seven independent loci (P 5.0 10(8)) near FTO (P 3.72 10(23)), TMEM18 (P 3.24 10(17)), MC4R (P 4.41 10(17)), TNNI3K (P 4.32 10(11)), SEC16B (P 6.24 10(9)), GNPDA2 (P 1.11 10(8)) and POMC (P 4.94 10(8)) as well as a potential secondary signal at the POMC locus (rs2118404, P 2.4 10(5) after conditioning on the established single-nucleotide polymorphism at this locus) in adolescents and young adults. To evaluate the impact of the established genetic loci on BMI at these young ages, we examined differences between the effect sizes of 32 published BMI loci in European adult populations (aged 1890) and those observed in our adolescent and young adult meta-analysis. Four loci (near PRKD1, TNNI3K, SEC16B and CADM2) had larger effects and one locus (near SH2B1) had a smaller effect on BMI during adolescence and young adulthood compared with older adults (P 0.05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages.
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