Journal
HUMAN MOLECULAR GENETICS
Volume 21, Issue 22, Pages 4980-4995Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/dds334
Keywords
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Funding
- National Institute of Health (NIH) [U19CA148127, 5R01CA055769, 5R01CA127219, 5R01CA133996, 5R01CA121197, P50 CA70907, R01CA121197, RO1 CA127219, U19 CA148127, RO1 CA55769, HHSN268200782096C, CA074386, CA092824, CA090578]
- Canadian Cancer Society Research Institute [020214]
- Ontario Institute of Cancer
- Cancer Care Ontario Chair Award
- Cancer Research UK [C1298/A8780, C1298/A8362]
- NCRN, HEAL
- Sanofi-Aventis
- Roy Castle Lung Cancer Foundation, UK
- Deutsche Krebshilfe [70-2919]
- Helmholtz-DAAD fellowship [A/07/97379]
- National Institute of Health (USA) [U19CA148127]
- GSF
- German Federal Ministry of Education, Science, Research and Technology
- State of Bavaria
- National Genome Research Network (NGFN)
- DFG [BI 576/2-1, BI 576/2-2]
- Helmholtzgemeinschaft (HGF)
- Federal office for Radiation Protection [BfS: STSch4454]
- Institut National du Cancer, France
- European Community [LSHG-CT-2005-512113]
- Norwegian Cancer Association and the Functional Genomics Programme of Research Council of Norway
- European Regional Development Fund
- State Budget of the Czech Republic (RECAMO) [CZ.1.05/2.1.00/03.0101]
- National Cancer Institute of the U.S. National Institutes of Health [R01 CA111703, UO1 CA63673]
- Fred Hutchinson Cancer Research Center
- US National Cancer Institute [R01 CA092039]
- FP7 grant [REGPOT 245536]
- Estonian Government [SF0180142s08]
- EU RDF
- IARC
- NCI, Division of Cancer Epidemiology and Genetics
- U.S. Public Health Service from the NCI [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- NCI [NO1-CN-25514]
- Georgetown University [NO1-CN-25522]
- Pacific Health Research Institute [NO1-CN-25515]
- Henry Ford Health System [NO1-CN-25512]
- University of Minnesota [NO1-CN-25513]
- Washington University [NO1-CN-25516]
- University of Pittsburgh [NO1-CN-25511]
- University of Utah [NO1-CN-25524]
- Marshfield Clinic Research Foundation [NO1-CN-25518]
- University of Alabama at Birmingham [NO1-CN-75022]
- University of Alabama at Birmingham, Westat, Inc. [NO1-CN-25476]
- University of California, Los Angeles [NO1-CN-25404]
- American Cancer Society
- NIH Genes, Environment and Health Initiative (GEI) [HG-06-033-NCI-01, RO1HL091172-01]
- CPRIT grant [RP100443]
- China National High-Tech Research and Development Program Grant [2009AA022705]
- National Key Basic Research Program Grant [2011CB503805]
- National Natural Science Foundation of China [30730080, 30972541, 30901233, 30872178]
Ask authors/readers for more resources
Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer.
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