Journal
HUMAN MOLECULAR GENETICS
Volume 20, Issue -, Pages R109-R115Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddr336
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Funding
- California Institute of Regenerative Medicine (CIRM) [RC1-00115-1, RL1-00649-1]
- Lookout Fund
- Mathers Foundation
- Helmsley Foundation
- Christopher and Dana Reeve Foundation (CDRF)
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The systematic generation of neurons from patients with neurological disorders can provide important insights into disease pathology, progression and mechanism. This review will discuss recent progress in modeling neurodegenerative and neurodevelopmental diseases using induced pluripotent stem cells (iPSCs) and highlight some of the current challenges in the field. Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment.
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