Related references
Note: Only part of the references are listed.Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
Dongshan Yang et al.
HUMAN MOLECULAR GENETICS (2010)
Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease
John P. Miller et al.
NEURON (2010)
Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
Juliette D. Godin et al.
NEURON (2010)
SCA1-like Disease in Mice Expressing Wild-Type Ataxin-1 with a Serine to Aspartic Acid Replacement at Residue 776
Lisa Duvick et al.
NEURON (2010)
The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease
Yan Wang et al.
NEUROSCIENCE BULLETIN (2010)
Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr
Iris Ben-Efraim et al.
BMC CELL BIOLOGY (2009)
Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
Hyunkyung Jeong et al.
CELL (2009)
Phosphorylation of Threonine 3 IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY
Charity T. Aiken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie Michels Thompson et al.
JOURNAL OF CELL BIOLOGY (2009)
Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Xiaofeng Gu et al.
NEURON (2009)
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Jennifer Bradford et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Nuclear accumulation of polyglutamine disease proteins and neuropathology
Lauren S. Havel et al.
MOLECULAR BRAIN (2009)
Huntington's disease: from pathology and genetics to potential therapies
Sara Imarisio et al.
BIOCHEMICAL JOURNAL (2008)
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
Emilie Colin et al.
EMBO JOURNAL (2008)
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
Chuan-En Wang et al.
JOURNAL OF CELL BIOLOGY (2008)
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
Michelle Gray et al.
JOURNAL OF NEUROSCIENCE (2008)
Rodent genetic models of Huntington disease
Mary Y. Heng et al.
NEUROBIOLOGY OF DISEASE (2008)
Polyglutarnine neurodegeneration: protein misfolding revisited
Aislinn J. Williams et al.
TRENDS IN NEUROSCIENCES (2008)
Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease
Mary Y. Heng et al.
JOURNAL OF NEUROSCIENCE (2007)
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
Sandrine L. Anne et al.
JOURNAL OF NEUROSCIENCE (2007)
The HdhQ150/Q150 knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes
Ben Woodman et al.
BRAIN RESEARCH BULLETIN (2007)
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
Rona K. Graham et al.
CELL (2006)
Mechanisms of disease: histone modifications in Huntington's disease
Ghazaleh Sadri-Vakili et al.
NATURE CLINICAL PRACTICE NEUROLOGY (2006)
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease
JM Van Raamsdonk et al.
HUMAN MOLECULAR GENETICS (2005)
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts
A Sawa et al.
NEUROBIOLOGY OF DISEASE (2005)
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease
CL Benn et al.
HUMAN MOLECULAR GENETICS (2005)
Polyglutamine expansion of huntingtin impairs its nuclear export
J Cornett et al.
NATURE GENETICS (2005)
Huntingtin and the molecular pathogenesis of Huntington's disease - Fourth in molecular medicine review series
C Landles et al.
EMBO REPORTS (2004)
Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
H Zhou et al.
JOURNAL OF CELL BIOLOGY (2003)
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease
EYW Chan et al.
HUMAN MOLECULAR GENETICS (2002)
Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
VC Wheeler et al.
HUMAN MOLECULAR GENETICS (2002)
Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
P Frosst et al.
JOURNAL OF CELL BIOLOGY (2002)
Mouse models of Huntington's disease
LB Menalled et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
Neurological abnormalities in a knock-in mouse model of Huntington's disease
CH Lin et al.
HUMAN MOLECULAR GENETICS (2001)
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
H Li et al.
NATURE GENETICS (2000)
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in Hdh(Q92) and Hdh(Q111) knock-in mice
VC Wheeler et al.
HUMAN MOLECULAR GENETICS (2000)
Share Paper
