Journal
HUMAN MOLECULAR GENETICS
Volume 19, Issue -, Pages R4-R11Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddq142
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Funding
- University of Antwerp
- Fund for Scientific Research-Flanders (FWO-V)
- Foundation for Alzheimer Research (SAO/FRMA)
- Belgian Federal Science Policy Office [P6/43]
- Flemish Government, Belgium
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Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genes-amyloid precursor protein and presenilin 1 and 2 genes-and one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
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