Journal
HUMAN MOLECULAR GENETICS
Volume 19, Issue -, Pages R204-R209Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddq404
Keywords
-
Funding
- NIH/NHGRI ENCODE Consortium [U54 HG004563-03]
Ask authors/readers for more resources
Next-generation sequencing-based assays to detect gene regulatory elements are enabling the analysis of individual-to-individual and allele-specific variation of chromatin status and transcription factor binding in humans. Recently, a number of studies have explored this area, using lymphoblastoid cell lines. Around 10% of chromatin sites show either individual-level differences or allele-specific behavior. Future studies are likely to be limited by cell line accessibility, meaning that white-bloodcell-based studies are likely to continue to be the main source of samples. A detailed understanding of the relationship between normal genetic variation and chromatin variation can shed light on how polymorphisms in non-coding regions in the human genome might underlie phenotypic variation and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available