Journal
HUMAN MOLECULAR GENETICS
Volume 18, Issue -, Pages R18-R26Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddp072
Keywords
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Funding
- National Basic Research Program of China [2007CB947502, 2006CB944000, 2007CB507400]
- National Natural Science Foundation of China (NSFC) [30630042, 30825026, 30800647]
- National Institutes of Health [R01 NS051630, R01 MH076090]
- Beckman Young Investigator Award
- Basil O'Connor Scholar Research Award
- Alfred P. Sloan Research Fellow in Neuroscience
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Increasingly complex networks of small RNAs act through RNA interference pathway to regulate gene expression. Recent evidence suggests that both development and proper function of central nervous system require intricate spatiotemporal expression of a wide repertoire of small regulatory RNAs. Misregulation of these small regulatory RNAs could contribute to the abnormalities in brain development that are associated with neurodevelopmental disorders. Here, we will review recent progress made toward understanding roles of small regulatory RNAs in neurodevelopmental disorders and discuss the potential involvement of newly discovered classes of small RNAs in these disorders.
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