4.5 Article

Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus

Related references

Note: Only part of the references are listed.
Article Neurosciences

Automated deformation analysis in the YAC128 Huntington disease mouse model

Jason P. Lerch et al.

NEUROIMAGE (2008)

Article Biochemistry & Molecular Biology

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

Randy Singh Atwal et al.

HUMAN MOLECULAR GENETICS (2007)

Article Biochemistry & Molecular Biology

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

Jessica E. Young et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Pathology

Activation of caspase-6 in aging and mild cognitive impairment

Steffen Albrecht et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

Review Biochemistry & Molecular Biology

Huntington's disease:: from huntingtin function and dysfunction to therapeutic strategies

M. Borrell-Pages et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Review Clinical Neurology

Canadian association of neurosciences review: Polyglutamine expansion neurodegenerative diseases

Ray Truant et al.

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (2006)

Article Biochemistry & Molecular Biology

Expression and characterization of full-length human Huntingtin, an elongated HEAT repeat protein

Wei Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664

V Galvan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Mutant Huntingtin: Nuclear translocation and cytotoxicity mediated by GAPDH

Y Bae et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

JM Van Raamsdonk et al.

HUMAN MOLECULAR GENETICS (2005)

Article Biochemistry & Molecular Biology

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease

CL Benn et al.

HUMAN MOLECULAR GENETICS (2005)

Article Multidisciplinary Sciences

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

EJ Slow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Genetics & Heredity

Polyglutamine expansion of huntingtin impairs its nuclear export

J Cornett et al.

NATURE GENETICS (2005)

Article Biochemistry & Molecular Biology

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

E Hermel et al.

CELL DEATH AND DIFFERENTIATION (2004)

Article Neurosciences

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease

PM Horowitz et al.

JOURNAL OF NEUROSCIENCE (2004)

Article Biochemistry & Molecular Biology

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

G Schilling et al.

HUMAN MOLECULAR GENETICS (2004)

Article Biochemistry & Molecular Biology

Inhibition of calpain cleavage of huntingtin reduces toxicity - Accumulation of calpain/caspase fragments in the nucleus

J Gafni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

EJ Slow et al.

HUMAN MOLECULAR GENETICS (2003)

Article Biochemistry & Molecular Biology

Huntingtin contains a highly conserved nuclear export signal

JR Xia et al.

HUMAN MOLECULAR GENETICS (2003)

Review Neurosciences

Role of proteolysis in polyglutamine disorders

V Tarlac et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

Article Cell Biology

Nuclear relocation of normal huntingtin

T Tao et al.

TRAFFIC (2001)

Article Neurosciences

ST14A cells have properties of a medium-size spiny neuron

ME Ehrlich et al.

EXPERIMENTAL NEUROLOGY (2001)

Article Biochemistry & Molecular Biology

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

CL Wellington et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Homology-based method for identification of protein repeats using statistical significance estimates

MA Andrade et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)