Journal
HUMAN MOLECULAR GENETICS
Volume 17, Issue 13, Pages 1988-1993Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddn096
Keywords
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Funding
- Intramural NIH HHS [Z01 AG000957-05] Funding Source: Medline
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A novel heterozygous non-synonymous mutation and a novel polymorphism in OMI/HTRA2 locus have been associated with Parkinson's disease (PD) in a German population. In an attempt to replicate these results in an independent population, we analyzed the entire coding region of OMI/HTRA2 in a series of 644 North American PD cases with both young- and late-onset disease and in 828 North American neurologically normal controls. Our results show that neither of the variants previously related to PD were associated with PD in our cohort and that the risk variants were present in neurologically normal controls.
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