Journal
HUMAN MOLECULAR GENETICS
Volume 17, Issue -, Pages R23-R27Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddn050
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.
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