Journal
HUMAN IMMUNOLOGY
Volume 72, Issue 8, Pages 627-631Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2011.03.028
Keywords
Human; Memory T cell; CD5; Interleukin-15; Bone marrow; Rheumatoid arthritis
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Funding
- Austrian Science Fund [S9308-B05]
- EU [FP6 036894]
- Austrian Federal Ministry of Science and Research
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Immunologic memory is a critical feature of the adaptive immune system to fight recurrent infections. However, the mechanisms that shape the composition and function of the human memory T-cell pool remain incompletely understood. We here demonstrate that post-thymic human T-cell differentiation was associated with the down-regulation, but not loss, of the inhibitory molecule CD5. The sensitivity of human CD8(+) and CD4(+) memory T cells to interleukin (IL)-15 was inversely associated with the level of CD5 expression. CD5 expression was down-regulated by IL-15-mediated signaling in vitro and CD5(lo) memory T cells accumulated in the bone marrow. Persistent antigenic stimulation, as in the case of cytomegalovirus infection and rheumatoid arthritis (RA), was also associated with an increased number of CD5(lo) memory T cells. In conclusion, CD5 may be a useful marker to identify memory T-cell subsets with distinct responsiveness to the homeostatic cytokine IL-15. (C) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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