Journal
HUMAN IMMUNOLOGY
Volume 71, Issue 2, Pages 192-194Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.11.001
Keywords
Killer cell immunoglobulin-like receptor (KIR); Natural killer (NK) cells; Vogt-Koyanagi-Harada (VKH) disease; Disease association
Categories
Funding
- Department of Pathology and Laboratory Medicine
- UCLA
- MacDonald Family Foundation
- Ministry of Health and Medical Education
- Islamic Republic of Iran
Ask authors/readers for more resources
Killer cell immunoglobulin-like receptors (KIR) control the effector function of natural killer (NK) cells and Subsets of T cell, and the genes encoding KIRs are substantially variable among individuals. A majority (58.4%) of Japanese individuals were found to be homozygous for group A KIR haplotypes that encode only a single activating KIR2DS4. Contrarily, most of Japanese patients with Vogt-Koyanagi-Harada (VKH) disease (69.2%), a panuveitis carry Bx genotypes that encode 2-5 activating KIR receptors. Particularly, individuals carrying three activating KIR genes 3DS1, 2DS1, and 2DS5 are more frequent in patient group compared with the controls (42.2% vs 21.4%, p = 0.02), In addition, the inhibitory KIR gene 3DL1 was significantly decreased in patients compared with controls (76.9% vs 98.8%, p = 0.00006). These data suggest that the genotypes encoding a dominant activating KIR receptor repertoire predispose susceptibility to VKH disease. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available