Journal
HUMAN IMMUNOLOGY
Volume 70, Issue 7, Pages 527-531Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2009.05.006
Keywords
Severe acute respiratory syndrome (SARS); Human leukocyte antigen (HLA); Association study; Genetic polymorphism; Viet Nam
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Funding
- HLA
- Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases, MEXT Japan
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Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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